VIRAL VECTOR & GENE EDITING CORE

Adeno-Associated Vectors

Overview

About Adeno-Associated Vector (AAV) – Why it’s the platform-of-choice for preclinical and gene therapy research

Adeno-associated vector (AAV) is a ssDNA, non-pathogenic, non-harmful viral delivery system that has emerged as a superb research tool and leading platform for genetic cargo delivery in preclinical and clinical applications. Several distinct attributes make AAV the gold-standard vector for both academic and industry investigators:

Non-Pathogenic, Non-Harmful; High Safety: AAV is not currently known to cause any disease in humans, making it a preferred choice for in vitro and in vivo delivery.
Low Immunogenicity and Toxicity: AAV vector transduction results in a minimal immune response, supporting higher dosing, stable and long-term gene expression, and minimal off-target side effects for research-grade and clinical-grade indications.
Broad and Modifiable Tropism: AAV can efficiently infect both dividing and non-dividing cells—which greatly fit into a broad range of applications.
Stable, Durable and Long Term Expression: AAV vectors can drive long-term, robust and stable gene expression without integrating the transgene-of-interest into the host chromosome, such reducing safety concerns and enabling effective therapeutic outcome.
Serotype-Driven Specificity: AAV can efficiently infect wide range of cells and tissues, and its capsids can be easily modified via serotype selection, such offering precise tissue or cell-type targeting for research use and gene therapy.

Product Information

Adeno-Associated Vector Prep Summary

Prep Type	Grade	Titer	Total Volume	Aliquot Size	Production Time	Academic Cost	Non-Academic Cost
Small AAV preps (I n Vitro Grade)	In Vitro	≥ 5 × 10¹¹ vg/mL	10 mL	1 mL	5 days	$360	$450
Large AAV preps (I n Vitro Grade)	In Vitro	≥ 5 × 10¹¹ vg/mL	100 mL	25 mL	5 days	$900	$1,125
Small AAV Preps (In Vivo Grade)	In Vivo	≥ 1 × 10 ¹³ vg/mL	100 µL	25 µL	10 days	$660	$825
Mid (Standard) AAV Preps (In Vivo Grade)	In Vivo	≥ 1 × 10 ¹³ vg/mL	500 µL	100 µL	10 days	$2,040	$2,550
Large AAV Preps (In Vivo Grade)	In Vivo	≥ 2.5 × 10 ¹³ vg/mL	2 mL	500 µL	14 days	$5,976	$7,440
Mega AAV Preps (In Vivo Grade)	In Vivo	≥ 2.5 × 10 ¹³ vg/mL	10 mL	1 mL	21 days	$17,980	$20,050

Internal FSU user rates are available, please contact us directly for a quote.

How to Order

To connect with IPRD’s Viral Vector & Gene Editing Core and place an order, simply email your request to viral.core@med.fsu.edu