Richard S Nowakowski Ph.D.
Randolph L. Rill Professor and Department Chair
Biosketch
1969-71: Research assistant, Wisconsin Regional Primate Research Center
1971-76: Predoctoral fellow, Department of Neuropathology, Harvard Medical School
1972: Summer research fellow, Institute for Biological Research, Belgrade, Yugoslavia
1976-79: Postdoctoral fellow, NIH Individual Fellowship, Departments of Psychology and Physiology, Duke University
1979-81: Wissenschaftlicher assistent, Max Planck Institute for Biophysical Chemistry, Goettingen, West Germany
1981-85: Assistant professor of anatomy, Department of Anatomy, University of Mississippi Medical Center
1985-2005: Associate professor, Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School
2004-2010: New Jersey Professor of Spinal Cord Research
2004-: Associate member, Keck Center for Collaborative Neuroscience, Rutgers University
2005-2010: Professor, Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School
2006-2010: Executive Committee, New Jersey Stem Cell Institute
2006-2010: Director, UMDNJ-RWJMS Postdoctoral Career Development Program
2010-: Adjunct professor, Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School
2010-: Randolph L. Rill Professor and Chair, Department of Biomedical Sciences, Florida State University College of Medicine
Education
1971: B.A., University of Wisconsin, psychology and chemistry
1976: Ph.D., Harvard University, cell and developmental biology
1976-79: Postdoctoral fellowship, Duke University, neuroscience
1979-81: Postdoctoral fellowship, Max Planck Institute for Biophysical Chemistry, neuroscience
Service
The Profession
Editor for Refereed Journals
Developmental Neuroscience (2008–present).
Senior Editor and Mini-Review Editor.
Editorial Board Membership(s)
Molecular Autism (2009–present).
Open Access Bioinformatics (2009–present).
Honorary Editorial Board.
Cerebral Cortex (2005–present).
Journal of Comparative Neurology (2002–present
Service to Professional Associations
Member, National Postdoctoral Association Board of Directors (2009–present).
Two year term.
Chair, Phenotyping Committee, Collaborative Cross of the Complex Trait Consortium (2005–present).
An international effor to produce and characterize mouse genetic resources
Member, NASA Amed Research Center Hypergravity Oversight Group (1998–present).
Scientific Advisory Board Member, Autism Speaks (1995–present).
formerly, National Alliance for Autism (NAAR).
Honors/Awards
Mary Shine Peterson Undergraduate Scholarship in Biochemistry
Phi Beta Kappa, Sigma Xi
Woodrow Wilson Fellowship, 1971-1972
National Science Foundation Fellowship, 1972-1975
Academia Rodinensis pro Remediatione, elected member 1984
Recipient of Research Career Development Award (RCDA) from NIH, 1985
Fellow, American Academy for the Advancement of Science
Special Lecture Award, Tokai University, Isehara, Japan
Plenary speaker, Hellenic Society for Neuroscience, 2002
New Jersey Professor of Spinal Cord Research
Plenary speaker, Second International Spinal Cord Injury Treatments and Trials Symposium
Plenary speaker, European Association of Pediatrics
Memberships
Member, NIH Study Section (Neurology B1), 1991-1995 (Chair, 1993-1995)
Scientific Advisory Board, National Alliance for Autism Research (1996-present)
Member, NASA Hypergravity Oversight Group, 1998-present
Member, NIH MDCN7 Study Section, 1999-2002 (Chair, 2000-2002)
Member, NSF Developmental Neuroscience Review Panel, 1999-2002
Editorial Board (1999-present) and senior editor (2002-present)
Developmental Neuroscience, Associate Editor, Journal of Neuroscience (2000-2008)
Editorial Board, Journal of Comparative Neurology (2002-present)
Member, NIH NTS Study Section (2003-2009)
Editorial Board, Cerebral Cortex (2004-present)
Board of Directors, National Postdoctoral Association (2009-present)
Research Focus
"Neuronogenesis in the Non-pigmented Retina”; Principal Investigator: Richard S. Nowakowski. Agency: NEI/NINDS. Funding period: 5/1/2004-5/30/2010 (includes one-year no-cost extension). This grant provides support for an analysis of the cell cycle and cell proliferation in genetic models of human ocular and cutaneous albinism, using pigmented and non-pigmented mouse retina.
“Phenomic Analysis of the Mouse Hippocampus”; Principal Investigator: Richard S. Nowakowski. Agency: NIH/NINDS. Funding period: 4/1/2004-3/30/2010 (includes one-year no-cost extension). This grant provides support for an analysis of the genetic variation of morphological phenotypes in the mouse hippocampus and dentate gyrus.
“Five-Year Named Chair for Senior Faculty”; Principal Investigator: Richard S. Nowakowski. Agency: New Jersey Commission on Spinal Cord Research. Funding period: 6/15/2005-9/30/2010 (five years plus no cost extension). This grant provides support for an analysis of the cell cycle and stem/progenitor cell proliferation after spinal cord injury.
Publications
Nowakowski, R.S.
and P. Rakic. The mode of migration of neurons to the hippocampus: a Golgi and electron microscopic analysis in foetal rhesus monkey. J.Neurocytol. 8: 697-718, 1979.
Nowakowski, R.S.
and P. Rakic. The site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey. J.Comp Neurol. 196: 129-154, 1981.
Rakic, P. and R.S. Nowakowski
. The time of origin of neurons in the hippocampal region of the rhesus monkey. J.Comp Neurol. 196: 99-128, 1981.
Miller, M.W. and R.S. Nowakowski
. Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system. Brain Res. 457: 44-52, 1988.
Nowakowski, R.S.
, S.B. Lewin, and M.W. Miller. Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population. J.Neurocytol. 18: 311-318, 1989.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone. J.Neurocytol. 21: 185-197, 1992.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. Cell cycle parameters and patterns of nuclear movement in the neocortical proliferative zone of the fetal mouse. J.Neurosci. 13: 820-833, 1993.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. Mode of cell proliferation in the developing mouse neocortex. Proc.Natl.Acad.Sci.U.S.A 91: 375-379, 1994.
Caviness, V.S. Jr., T. Takahashi, and R.S. Nowakowski
. Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model. Trends Neurosci. 18: 379-383, 1995.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall. J.Neurosci. 15: 6046-6057, 1995.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. Early ontogeny of the secondary proliferative population of the embryonic murine cerebral wall. J.Neurosci. 15: 6058-6068, 1995.
Caviness, V. S. Jr., T. Takahashi, S. Miyama, R.S. Nowakowski
, and I. Delalle. Regulation of normal proliferation in the developing cerebrum potential actions of trophic factors. Exp.Neurol. 137: 357-366, 1996.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. Interkinetic and migratory behavior of a cohort of neocortical neurons arising in the early embryonic murine cerebral wall. J.Neurosci. 16: 5762-5776, 1996.
Takahashi, T., R.S. Nowakowski
and V.S. Caviness Jr. The leaving or Q fraction of the murine cerebral proliferative epithelium: a general model of neocortical neuronogenesis. J.Neurosci. 16: 6183-6196, 1996.
Cai, L., N.L. Hayes, and R.S. Nowakowski
. Local homogeneity of cell cycle length in developing mouse cortex. J.Neurosci. 17: 2079-2087, 1997.
Cai, L., N.L. Hayes, and R.S. Nowakowski
. Synchrony of clonal cell proliferation and contiguity of clonally related cells: production of mosaicism in the ventricular zone of developing mouse neocortex. J.Neurosci. 17: 2088-2100, 1997.
Miyama, S., T. Takahashi, R.S. Nowakowski
, and V.S. Caviness Jr. A gradient in the duration of the G1 phase in the murine neocortical proliferative epithelium. Cereb.Cortex 7: 678-689, 1997.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. The mathematics of neocortical neuronogenesis. Dev.Neurosci. 19: 17-22, 1997.
Caviness, V.S. Jr., T. Takahashi, and R.S. Nowakowski
. The G1 restriction point as critical regulator of neocortical neuronogenesis. Neurochem.Res. 24: 497-506, 1999.
Delalle, I., T. Takahashi, R.S. Nowakowski
, L.H. Tsai, and V.S. Caviness Jr. Cyclin E-p27 opposition and regulation of the G1 phase of the cell cycle in the murine neocortical PVE: a quantitative analysis of mRNA in situ hybridization. Cereb.Cortex 9: 824-832, 1999.
Nowakowski, R.S.
and N.L. Hayes. CNS development: an overview. Dev.Psychopathol. 11: 395-417, 1999.
Takahashi, T., T. Goto, S. Miyama, R.S. Nowakowski
, and V.S. Caviness Jr. Sequence of neuron origin and neocortical laminar fate: relation to cell cycle of origin in the developing murine cerebral wall. J.Neurosci. 19: 10357-10371, 1999.
Gilmore, E.C., R.S. Nowakowski
, V.S. Caviness Jr., and K. Herrup. Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together? Trends Neurosci. 23: 100-105, 2000.
Hayes, N.L. and R.S. Nowakowski
. Exploiting the dynamics of S-phase tracers in developing brain: interkinetic nuclear migration for cells entering versus leaving the S- phase. Dev.Neurosci. 22: 44-55, 2000.
Verney, C., T. Takahashi, P.G. Bhide, R.S. Nowakowski
, and V.S. Caviness Jr. Independent controls for neocortical neuron production and histogenetic cell death. Dev.Neurosci. 22: 125-138, 2000.
Levison, S., Nowakowski, R.S.
, Whither stem cell biology?. Dev Neurosci 22: 5-6, 2000.
Haydar TF, Nowakowski RS
, Yarowsky PJ, Krueger BK Role of Founder Cell Deficit and Delayed Neuronogenesis in Microencephaly of the Trisomy 16 Mouse. J. Neurosci. 20: 4156-4164, 2000.
Gilmore, E., R.S. Nowakowski
, V.S. Caviness Jr. and K. Herrup. Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together? Trends in Neuroscience 23: 100-105, 2000.
Caviness, V.S. Jr., T. Takahashi and R.S. Nowakowski
. Neocortical malformation as consequence of non-adaptive regulation of neuronogenetic sequence. In: Pathology of Development of Cerebral Cortex. Mental Retard. Devel. Disabil. 6: 22-33, 2000.
Nowakowski, R.S.
and Hayes, N.L. New Neurons: Extraordinary Evidence or Extraordinary Conclusion? Science 288:771a-773a, 2000.
Caviness, V.S. Jr., T. Takahashi and R.S. Nowakowski
. Neuronogenesis and the early events of neocortical histogenesis. In: Development of Cerebral Cortex (Ed. A. Goffinet and P. Rakic). In: Results and Problems in Cell Differentiation. 30: 107-143, 2000.
Takahashi, T., Nowakowski, R.S.
, and Caviness, V.S. Jr. Neocortical Neuronogenesis: Regulation, Control Points and a Strategy of Structural Variation. In: Handbook of Cognitive Developmental Neuroscience (Nelson CA, Luciana M, eds), in press. Cambridge, MA: MIT Press, p. 3-22, 2001.
Cahana, A., T. Escamez, R.S. Nowakowski
, N.L. Hayes, M.B. Giacobini, A. von Holst, O. Shmueli, T. Sapir, S.K. McConnell, W. Wurst, S. Martinez, and O. Reiner. Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. PNAS, 98: 6429-34, 2001.
RS Nowakowski
and NL Hayes. Stem Cells: The Promises and Pitfalls (Commentary). Neuropsycho-pharmacology, 25:799-804, 2001.
Hayes, NL and RS Nowakowski
. Dynamics of cell proliferation in the adult dentate gyrus of two inbred strains of mice. Dev. Brain Research. 134:77-85, 2002.
Caviness, V.S. Jr., R.S. Nowakowski
and T. Takahashi. Neocortical neuronogenesis: the G1 restriction point as master integrative mechanism. In: The Newborn Brain - Scientific Basis and Clinical Applications (H. Lagerkrantz, Editor), 2002.
RS Nowakowski
, VS Caviness Jr., T Takahashi and NL Hayes. Population Dynamics during Cell Proliferation and Neuronogenesis in the Developing Murine Neocortex. In: Cerebral Cortex, Vol. 1 of Series: Results and Problems in Cell Differentiation, (C. Hohmann, Editor), 2002.
Rachel, RA, G. Dölen, NL Hayes, A. Lu, L Erskine, RS Nowakowski
, and CA Mason. Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina. J. Neuroscience, 22: 4249-4263, 2002.
Goto, T, T. Takahashi, S. Miyama, P. Bhide, RS Nowakowski
, VS Caviness, Jr. FGF-2 and gap junction blockade and regulation of cell production in explants of the murine proliferative ventricular epithelium: implications for an hypothesis relating to mitogen-antimitogen opposition. J. Neuroscience Research, 69:714-22, 2002.
Cai, L., N.L. Hayes, T. Takahashi, V.S. Caviness Jr. and R.S. Nowakowski
. Size Distribution of Retrovirally Marked Lineages Matches Prediction from Population Measurements of Cell Cycle Behavior in Early Developing Mouse Neocortex. J. Neuroscience Research, 69:731-44, 2003.
Caviness, V.S. Jr., T. Goto, T. Tarui, T. Takahashi, P.G. Bhide and R.S. Nowakowski
. Cell Output, Cell Cycle Duration and Neuronal Specification: A Model of Integrated Mechanisms of the Neocortical Proliferative Process. Cerebral Cortex 13:592–598, 2003.
Complex Trait Consortium (79 authors including R.S. Nowakowski
). The nature and identification of quantitative trait loci: a community’s view. Nature Reviews Genetics 4: 911-916, 2003.
Complex Trait Consortium (104 authors including R.S. Nowakowski
). The Collaborative Cross: A Community Resource for the Genetic Analysis of Complex Traits. Nature Genetics, 11:1133-7, 2004.
Bhide, P.G. and R.S. Nowakowski
. Neural Stem Cells: A Perspective and Synopsis of the Current Status. Dev Neurosci. 26:81, 2004.
Zheng, W., R.S. Nowakowski
, and F.M. Vaccarino. Fibroblast Growth Factor 2 Is Required for Maintaining the Neural Stem Cell Pool in the Mouse Brain Subventricular Zone. Dev Neurosci 26:181-196, 2004.
Sekiguchi, M., Takagi, K, Takagi, N., Date, I., Takeo, S., Tanaka, O., Yamato, I., Kobashikawa, S., Kojun Torigoe, K. and Nowakowski, R.S.
Time course and sequence of pathological changes in the cerebellum of microsphere-embolized rats. Exp. Neurol., 191: 266-275, 2005.
Tarui, T., Takahashi, T., Nowakowski, R.S.
, Hayes, N.L., Bhide, P.G., Caviness, V.S. Jr. Overexpression of p27Kip1 alters laminar fate of neocortical neurons by altering probability of cell cycle exit. Cerebral Cortex, 15:1343-1355, 2005.
Nowakowski, R.S.
Stable Neuron Numbers from Cradle to Grave PNAS, 103:12219-12220, 2006.
Suter, B, Nowakowski, R.S.
, Bhide, P.G., and Caviness, V.S Jr. Navigating Neocortical Neurogenesis and Neuronal Specification: A Positional Information System Encoded by Neurogenetic Gradients. J. Neuroscience. J Neurosci. 27:10777-84, 2007.
Nowakowski, R.S.
and N.L. Hayes. Cell Cycle and Neurogenesis. In: Adult Neurogenesis (Eds. F.H. Gage, G. Kemperman, and H. Song). Cold Spring Harbor Press, New York, pp. 7-23, 2007.
Caviness V.S., Bhide P.G., Nowakowski R.S.
Histogenetic processes leading to the laminated neocortex: migration is only a part of the story. Dev Neurosci. 30:82-95, 2008.
Nowakowski, R.S.
and Hayes, N.L. Radiation, retardation and the developing brain: time is the crucial variable. Acta Paediatrica, 97: 527-531, 2008.
Caviness, V.S., P.G. Bhide and R.S. Nowakowski
. Neocortical neurogenesis: morphogenetic gradients and beyond. Trends in Neuroscience, 32:443-450, 2009.
Cooper MA, Crockett DP, Nowakowski RS
, Gale NW, Zhou R. Distribution of EphA5 receptor protein in the developing and adult mouse nervous system. J Comp Neurol. 514:310-28, 2009.
Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS
, Whatley S, Williams RW. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci. 3:55, 2009.
Nguyen, T.T., R.S. Nowakowski
and I.P. Androulakis. Unsupervised selection of highly coexpressed and noncoexpressed genes using a consensus clustering approach OMICS 13:219-237, 2009.
Caviness VS Jr, Nowakowski RS
, Bhide PG. Neocortical neurogenesis: morphogenetic gradients and beyond. Trends Neurosci. 32:443-50, 2009.
Poon A, Li Z, Wolfe GW, Lu L, Williams RW, Hayes NL, Nowakowski RS
, Goldowitz D. Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. Eur J Neurosci. 32:523-37, 2010.
Kulkarni, V, N.L. Hayes and R.S. Nowakowski
, in preparation. Regionalization of the Ventricular Zone by Cell Cycle Dynamics in the Developing Mouse Hippocampus. Submitted to Cerebral Cortex.
Hayes, NL, and RS Nowakowski
, in preparation. Genetic controls of Adult Neurogenesis in the mouse. To be submitted to J. Neurosci.
Megraw, T. L., Sharkey, J. T., & Nowakowski, R. S.
(2011). Cdk5rap2 exposes the centrosomal root of microcephaly syndromes. Trends Cell Biol, 10. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21632253Trends in cell biology Trends Cell Biol. 2011 May 31.
Poon, A., Li, Z., Wolfe, G. W., Lu, L., Williams, R. W., Hayes, N. L., Nowakowski, R. S.
, & Goldowitz, D. (2010). Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. Eur J Neurosci, 32(4), 523-37. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20718853
The European journal of neuroscience Poon, Anna Zhiyou fe, Gregory W Lu liams, Robert W es, Nancy L akowski, Richard S dowitz, Daniel 8245/AG/NIA NIH HHS/ DA021131/DA/NIDA NIH HHS/ DA020677/DA/NIDA NIH HHS/ AA014425/AA/NIAAA NIH HHS/ nce J Neurosci. 2010 Aug;32(4):523-37.
1969-71: Research assistant, Wisconsin Regional Primate Research Center
1971-76: Predoctoral fellow, Department of Neuropathology, Harvard Medical School
1972: Summer research fellow, Institute for Biological Research, Belgrade, Yugoslavia
1976-79: Postdoctoral fellow, NIH Individual Fellowship, Departments of Psychology and Physiology, Duke University
1979-81: Wissenschaftlicher assistent, Max Planck Institute for Biophysical Chemistry, Goettingen, West Germany
1981-85: Assistant professor of anatomy, Department of Anatomy, University of Mississippi Medical Center
1985-2005: Associate professor, Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School
2004-2010: New Jersey Professor of Spinal Cord Research
2004-: Associate member, Keck Center for Collaborative Neuroscience, Rutgers University
2005-2010: Professor, Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School
2006-2010: Executive Committee, New Jersey Stem Cell Institute
2006-2010: Director, UMDNJ-RWJMS Postdoctoral Career Development Program
2010-: Adjunct professor, Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School
2010-: Randolph L. Rill Professor and Chair, Department of Biomedical Sciences, Florida State University College of Medicine
1971: B.A., University of Wisconsin, psychology and chemistry
1976: Ph.D., Harvard University, cell and developmental biology
1976-79: Postdoctoral fellowship, Duke University, neuroscience
1979-81: Postdoctoral fellowship, Max Planck Institute for Biophysical Chemistry, neuroscience
The Profession
Editor for Refereed Journals
Developmental Neuroscience (2008–present).
Senior Editor and Mini-Review Editor.
Editorial Board Membership(s)
Molecular Autism (2009–present).
Open Access Bioinformatics (2009–present).
Honorary Editorial Board.
Cerebral Cortex (2005–present).
Journal of Comparative Neurology (2002–present
Service to Professional Associations
Member, National Postdoctoral Association Board of Directors (2009–present).
Two year term.
Chair, Phenotyping Committee, Collaborative Cross of the Complex Trait Consortium (2005–present).
An international effor to produce and characterize mouse genetic resources
Member, NASA Amed Research Center Hypergravity Oversight Group (1998–present).
Scientific Advisory Board Member, Autism Speaks (1995–present).
formerly, National Alliance for Autism (NAAR).
Mary Shine Peterson Undergraduate Scholarship in Biochemistry
Phi Beta Kappa, Sigma Xi
Woodrow Wilson Fellowship, 1971-1972
National Science Foundation Fellowship, 1972-1975
Academia Rodinensis pro Remediatione, elected member 1984
Recipient of Research Career Development Award (RCDA) from NIH, 1985
Fellow, American Academy for the Advancement of Science
Special Lecture Award, Tokai University, Isehara, Japan
Plenary speaker, Hellenic Society for Neuroscience, 2002
New Jersey Professor of Spinal Cord Research
Plenary speaker, Second International Spinal Cord Injury Treatments and Trials Symposium
Plenary speaker, European Association of Pediatrics
Member, NIH Study Section (Neurology B1), 1991-1995 (Chair, 1993-1995)
Scientific Advisory Board, National Alliance for Autism Research (1996-present)
Member, NASA Hypergravity Oversight Group, 1998-present
Member, NIH MDCN7 Study Section, 1999-2002 (Chair, 2000-2002)
Member, NSF Developmental Neuroscience Review Panel, 1999-2002
Editorial Board (1999-present) and senior editor (2002-present)
Developmental Neuroscience, Associate Editor, Journal of Neuroscience (2000-2008)
Editorial Board, Journal of Comparative Neurology (2002-present)
Member, NIH NTS Study Section (2003-2009)
Editorial Board, Cerebral Cortex (2004-present)
Board of Directors, National Postdoctoral Association (2009-present)
"Neuronogenesis in the Non-pigmented Retina”; Principal Investigator: Richard S. Nowakowski. Agency: NEI/NINDS. Funding period: 5/1/2004-5/30/2010 (includes one-year no-cost extension). This grant provides support for an analysis of the cell cycle and cell proliferation in genetic models of human ocular and cutaneous albinism, using pigmented and non-pigmented mouse retina.
“Phenomic Analysis of the Mouse Hippocampus”; Principal Investigator: Richard S. Nowakowski. Agency: NIH/NINDS. Funding period: 4/1/2004-3/30/2010 (includes one-year no-cost extension). This grant provides support for an analysis of the genetic variation of morphological phenotypes in the mouse hippocampus and dentate gyrus.
“Five-Year Named Chair for Senior Faculty”; Principal Investigator: Richard S. Nowakowski. Agency: New Jersey Commission on Spinal Cord Research. Funding period: 6/15/2005-9/30/2010 (five years plus no cost extension). This grant provides support for an analysis of the cell cycle and stem/progenitor cell proliferation after spinal cord injury.
Nowakowski, R.S.
and P. Rakic. The mode of migration of neurons to the hippocampus: a Golgi and electron microscopic analysis in foetal rhesus monkey. J.Neurocytol. 8: 697-718, 1979.
Nowakowski, R.S.
and P. Rakic. The site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey. J.Comp Neurol. 196: 129-154, 1981.
Rakic, P. and R.S. Nowakowski
. The time of origin of neurons in the hippocampal region of the rhesus monkey. J.Comp Neurol. 196: 99-128, 1981.
Miller, M.W. and R.S. Nowakowski
. Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system. Brain Res. 457: 44-52, 1988.
Nowakowski, R.S.
, S.B. Lewin, and M.W. Miller. Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population. J.Neurocytol. 18: 311-318, 1989.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone. J.Neurocytol. 21: 185-197, 1992.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. Cell cycle parameters and patterns of nuclear movement in the neocortical proliferative zone of the fetal mouse. J.Neurosci. 13: 820-833, 1993.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. Mode of cell proliferation in the developing mouse neocortex. Proc.Natl.Acad.Sci.U.S.A 91: 375-379, 1994.
Caviness, V.S. Jr., T. Takahashi, and R.S. Nowakowski
. Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model. Trends Neurosci. 18: 379-383, 1995.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall. J.Neurosci. 15: 6046-6057, 1995.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. Early ontogeny of the secondary proliferative population of the embryonic murine cerebral wall. J.Neurosci. 15: 6058-6068, 1995.
Caviness, V. S. Jr., T. Takahashi, S. Miyama, R.S. Nowakowski
, and I. Delalle. Regulation of normal proliferation in the developing cerebrum potential actions of trophic factors. Exp.Neurol. 137: 357-366, 1996.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. Interkinetic and migratory behavior of a cohort of neocortical neurons arising in the early embryonic murine cerebral wall. J.Neurosci. 16: 5762-5776, 1996.
Takahashi, T., R.S. Nowakowski
and V.S. Caviness Jr. The leaving or Q fraction of the murine cerebral proliferative epithelium: a general model of neocortical neuronogenesis. J.Neurosci. 16: 6183-6196, 1996.
Cai, L., N.L. Hayes, and R.S. Nowakowski
. Local homogeneity of cell cycle length in developing mouse cortex. J.Neurosci. 17: 2079-2087, 1997.
Cai, L., N.L. Hayes, and R.S. Nowakowski
. Synchrony of clonal cell proliferation and contiguity of clonally related cells: production of mosaicism in the ventricular zone of developing mouse neocortex. J.Neurosci. 17: 2088-2100, 1997.
Miyama, S., T. Takahashi, R.S. Nowakowski
, and V.S. Caviness Jr. A gradient in the duration of the G1 phase in the murine neocortical proliferative epithelium. Cereb.Cortex 7: 678-689, 1997.
Takahashi, T., R.S. Nowakowski
, and V.S. Caviness Jr. The mathematics of neocortical neuronogenesis. Dev.Neurosci. 19: 17-22, 1997.
Caviness, V.S. Jr., T. Takahashi, and R.S. Nowakowski
. The G1 restriction point as critical regulator of neocortical neuronogenesis. Neurochem.Res. 24: 497-506, 1999.
Delalle, I., T. Takahashi, R.S. Nowakowski
, L.H. Tsai, and V.S. Caviness Jr. Cyclin E-p27 opposition and regulation of the G1 phase of the cell cycle in the murine neocortical PVE: a quantitative analysis of mRNA in situ hybridization. Cereb.Cortex 9: 824-832, 1999.
Nowakowski, R.S.
and N.L. Hayes. CNS development: an overview. Dev.Psychopathol. 11: 395-417, 1999.
Takahashi, T., T. Goto, S. Miyama, R.S. Nowakowski
, and V.S. Caviness Jr. Sequence of neuron origin and neocortical laminar fate: relation to cell cycle of origin in the developing murine cerebral wall. J.Neurosci. 19: 10357-10371, 1999.
Gilmore, E.C., R.S. Nowakowski
, V.S. Caviness Jr., and K. Herrup. Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together? Trends Neurosci. 23: 100-105, 2000.
Hayes, N.L. and R.S. Nowakowski
. Exploiting the dynamics of S-phase tracers in developing brain: interkinetic nuclear migration for cells entering versus leaving the S- phase. Dev.Neurosci. 22: 44-55, 2000.
Verney, C., T. Takahashi, P.G. Bhide, R.S. Nowakowski
, and V.S. Caviness Jr. Independent controls for neocortical neuron production and histogenetic cell death. Dev.Neurosci. 22: 125-138, 2000.
Levison, S., Nowakowski, R.S.
, Whither stem cell biology?. Dev Neurosci 22: 5-6, 2000.
Haydar TF, Nowakowski RS
, Yarowsky PJ, Krueger BK Role of Founder Cell Deficit and Delayed Neuronogenesis in Microencephaly of the Trisomy 16 Mouse. J. Neurosci. 20: 4156-4164, 2000.
Gilmore, E., R.S. Nowakowski
, V.S. Caviness Jr. and K. Herrup. Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together? Trends in Neuroscience 23: 100-105, 2000.
Caviness, V.S. Jr., T. Takahashi and R.S. Nowakowski
. Neocortical malformation as consequence of non-adaptive regulation of neuronogenetic sequence. In: Pathology of Development of Cerebral Cortex. Mental Retard. Devel. Disabil. 6: 22-33, 2000.
Nowakowski, R.S.
and Hayes, N.L. New Neurons: Extraordinary Evidence or Extraordinary Conclusion? Science 288:771a-773a, 2000.
Caviness, V.S. Jr., T. Takahashi and R.S. Nowakowski
. Neuronogenesis and the early events of neocortical histogenesis. In: Development of Cerebral Cortex (Ed. A. Goffinet and P. Rakic). In: Results and Problems in Cell Differentiation. 30: 107-143, 2000.
Takahashi, T., Nowakowski, R.S.
, and Caviness, V.S. Jr. Neocortical Neuronogenesis: Regulation, Control Points and a Strategy of Structural Variation. In: Handbook of Cognitive Developmental Neuroscience (Nelson CA, Luciana M, eds), in press. Cambridge, MA: MIT Press, p. 3-22, 2001.
Cahana, A., T. Escamez, R.S. Nowakowski
, N.L. Hayes, M.B. Giacobini, A. von Holst, O. Shmueli, T. Sapir, S.K. McConnell, W. Wurst, S. Martinez, and O. Reiner. Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. PNAS, 98: 6429-34, 2001.
RS Nowakowski
and NL Hayes. Stem Cells: The Promises and Pitfalls (Commentary). Neuropsycho-pharmacology, 25:799-804, 2001.
Hayes, NL and RS Nowakowski
. Dynamics of cell proliferation in the adult dentate gyrus of two inbred strains of mice. Dev. Brain Research. 134:77-85, 2002.
Caviness, V.S. Jr., R.S. Nowakowski
and T. Takahashi. Neocortical neuronogenesis: the G1 restriction point as master integrative mechanism. In: The Newborn Brain - Scientific Basis and Clinical Applications (H. Lagerkrantz, Editor), 2002.
RS Nowakowski
, VS Caviness Jr., T Takahashi and NL Hayes. Population Dynamics during Cell Proliferation and Neuronogenesis in the Developing Murine Neocortex. In: Cerebral Cortex, Vol. 1 of Series: Results and Problems in Cell Differentiation, (C. Hohmann, Editor), 2002.
Rachel, RA, G. Dölen, NL Hayes, A. Lu, L Erskine, RS Nowakowski
, and CA Mason. Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina. J. Neuroscience, 22: 4249-4263, 2002.
Goto, T, T. Takahashi, S. Miyama, P. Bhide, RS Nowakowski
, VS Caviness, Jr. FGF-2 and gap junction blockade and regulation of cell production in explants of the murine proliferative ventricular epithelium: implications for an hypothesis relating to mitogen-antimitogen opposition. J. Neuroscience Research, 69:714-22, 2002.
Cai, L., N.L. Hayes, T. Takahashi, V.S. Caviness Jr. and R.S. Nowakowski
. Size Distribution of Retrovirally Marked Lineages Matches Prediction from Population Measurements of Cell Cycle Behavior in Early Developing Mouse Neocortex. J. Neuroscience Research, 69:731-44, 2003.
Caviness, V.S. Jr., T. Goto, T. Tarui, T. Takahashi, P.G. Bhide and R.S. Nowakowski
. Cell Output, Cell Cycle Duration and Neuronal Specification: A Model of Integrated Mechanisms of the Neocortical Proliferative Process. Cerebral Cortex 13:592–598, 2003.
Complex Trait Consortium (79 authors including R.S. Nowakowski
). The nature and identification of quantitative trait loci: a community’s view. Nature Reviews Genetics 4: 911-916, 2003.
Complex Trait Consortium (104 authors including R.S. Nowakowski
). The Collaborative Cross: A Community Resource for the Genetic Analysis of Complex Traits. Nature Genetics, 11:1133-7, 2004.
Bhide, P.G. and R.S. Nowakowski
. Neural Stem Cells: A Perspective and Synopsis of the Current Status. Dev Neurosci. 26:81, 2004.
Zheng, W., R.S. Nowakowski
, and F.M. Vaccarino. Fibroblast Growth Factor 2 Is Required for Maintaining the Neural Stem Cell Pool in the Mouse Brain Subventricular Zone. Dev Neurosci 26:181-196, 2004.
Sekiguchi, M., Takagi, K, Takagi, N., Date, I., Takeo, S., Tanaka, O., Yamato, I., Kobashikawa, S., Kojun Torigoe, K. and Nowakowski, R.S.
Time course and sequence of pathological changes in the cerebellum of microsphere-embolized rats. Exp. Neurol., 191: 266-275, 2005.
Tarui, T., Takahashi, T., Nowakowski, R.S.
, Hayes, N.L., Bhide, P.G., Caviness, V.S. Jr. Overexpression of p27Kip1 alters laminar fate of neocortical neurons by altering probability of cell cycle exit. Cerebral Cortex, 15:1343-1355, 2005.
Nowakowski, R.S.
Stable Neuron Numbers from Cradle to Grave PNAS, 103:12219-12220, 2006.
Suter, B, Nowakowski, R.S.
, Bhide, P.G., and Caviness, V.S Jr. Navigating Neocortical Neurogenesis and Neuronal Specification: A Positional Information System Encoded by Neurogenetic Gradients. J. Neuroscience. J Neurosci. 27:10777-84, 2007.
Nowakowski, R.S.
and N.L. Hayes. Cell Cycle and Neurogenesis. In: Adult Neurogenesis (Eds. F.H. Gage, G. Kemperman, and H. Song). Cold Spring Harbor Press, New York, pp. 7-23, 2007.
Caviness V.S., Bhide P.G., Nowakowski R.S.
Histogenetic processes leading to the laminated neocortex: migration is only a part of the story. Dev Neurosci. 30:82-95, 2008.
Nowakowski, R.S.
and Hayes, N.L. Radiation, retardation and the developing brain: time is the crucial variable. Acta Paediatrica, 97: 527-531, 2008.
Caviness, V.S., P.G. Bhide and R.S. Nowakowski
. Neocortical neurogenesis: morphogenetic gradients and beyond. Trends in Neuroscience, 32:443-450, 2009.
Cooper MA, Crockett DP, Nowakowski RS
, Gale NW, Zhou R. Distribution of EphA5 receptor protein in the developing and adult mouse nervous system. J Comp Neurol. 514:310-28, 2009.
Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS
, Whatley S, Williams RW. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci. 3:55, 2009.
Nguyen, T.T., R.S. Nowakowski
and I.P. Androulakis. Unsupervised selection of highly coexpressed and noncoexpressed genes using a consensus clustering approach OMICS 13:219-237, 2009.
Caviness VS Jr, Nowakowski RS
, Bhide PG. Neocortical neurogenesis: morphogenetic gradients and beyond. Trends Neurosci. 32:443-50, 2009.
Poon A, Li Z, Wolfe GW, Lu L, Williams RW, Hayes NL, Nowakowski RS
, Goldowitz D. Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. Eur J Neurosci. 32:523-37, 2010.
Kulkarni, V, N.L. Hayes and R.S. Nowakowski
, in preparation. Regionalization of the Ventricular Zone by Cell Cycle Dynamics in the Developing Mouse Hippocampus. Submitted to Cerebral Cortex.
Hayes, NL, and RS Nowakowski
, in preparation. Genetic controls of Adult Neurogenesis in the mouse. To be submitted to J. Neurosci.
Megraw, T. L., Sharkey, J. T., & Nowakowski, R. S.
(2011). Cdk5rap2 exposes the centrosomal root of microcephaly syndromes. Trends Cell Biol, 10. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21632253Trends in cell biology Trends Cell Biol. 2011 May 31.
Poon, A., Li, Z., Wolfe, G. W., Lu, L., Williams, R. W., Hayes, N. L., Nowakowski, R. S.
, & Goldowitz, D. (2010). Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. Eur J Neurosci, 32(4), 523-37. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20718853
The European journal of neuroscience Poon, Anna Zhiyou fe, Gregory W Lu liams, Robert W es, Nancy L akowski, Richard S dowitz, Daniel 8245/AG/NIA NIH HHS/ DA021131/DA/NIDA NIH HHS/ DA020677/DA/NIDA NIH HHS/ AA014425/AA/NIAAA NIH HHS/ nce J Neurosci. 2010 Aug;32(4):523-37.